`` Excess Urinary Protein | Acthar® Gel (repository corticotropin injection)

Relief for excess urinary protein

Acthar Gel is FDA approved to reduce excess urinary protein (proteinuria) in people with nephrotic syndrome.

John, treated with Acthar Gel.
Individual results may vary. Compensated by Keenova.

Links On this page What is Acthar Gel

What is Acthar Gel?

Acthar Gel is a prescription medicine used for the reduction of proteinuria in people with nephrotic syndrome of the idiopathic type (unknown origin) without uremia (accumulation of urea in the blood due to malfunctioning kidneys) or that due to lupus erythematosus (lupus).

Ask about Acthar Gel

Make the most of your next doctor's appointment. Download this brochure and bring it to your next visit.

Look inside to find information about:
  • What Acthar Gel is and how it is believed to work
  • How to take it
  • Patient support programs
  • Tips for talking with your doctor
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Are you struggling with these common signs and/or symptoms of nephrotic syndrome?

The kidneys normally filter waste and extra water from the blood, which become urine. When the kidneys’ filtering units are inflamed, they can’t clean the blood properly and essential proteins leak into the urine along with the waste. When this happens, people may also experience a group of symptoms called nephrotic syndrome.

Signs and symptoms of nephrotic syndrome can vary from person to person. If you have these symptoms, ask your doctor about Acthar Gel. Symptoms commonly include:

Fatigue Fatigue
Loss of appetite Loss of appetite
Foamy urine Foamy urine
Weight gain Weight gain
Swelling in legs, feet, or ankles Swelling in legs, feet,
or ankles

What is nephrotic syndrome?

Nephrotic syndrome can occur when your kidneys are damaged and not working as well as they should. If nephrotic syndrome continues, it can sometimes lead to serious kidney problems.

Many diseases and conditions associated with nephrotic syndrome can trigger kidney damage and excess protein in the urine. These conditions include:

Focal segmental glomerulosclerosis (FSGS) Focal segmental glomerulosclerosis (FSGS)

In FSGS, parts of the tiny filters in your kidneys (glomeruli) get damaged. Doctors aren’t always sure what causes it. If the damage gets worse, it can lead to permanent kidney problems or even kidney failure.

IgA nephropathy IgA nephropathy

In IgAN, a protein called immunoglobulin A, or IgA—a normal part of your immune system—builds up in your kidneys. This build-up causes scarring and damage in the kidney tissues. If it becomes severe, it can also lead to kidney failure.

Nephrotic syndrome can also occur in membranous nephropathy, minimal change disease, membranoproliferative glomerulonephritis (MPGN), fibrillary glomerulonephritis (FGN), and other glomerular disorders.

Real patient stories

You're not alone. Hear from real people about their experiences and the impact Acthar Gel has had for them.

Play video
Meet Don

In this video, Don talks about how his life changed when he was diagnosed with high urine protein levels. Acthar Gel helped him achieve remission. Individual results may vary.

Additional patient stories

Meet John

Meet John

quote icon

All my life I’ve been inspired by brave people who taught me to always persevere.”

A serious medical diagnosis can seem devastating; what matters most to me is how I choose to keep myself going. When my nephrologist diagnosed me with proteinuria due to nephrotic syndrome, I was scared. My doctor soon recommended treatment with Acthar® Gel (repository corticotropin injection), saying that he felt that it might be a good option for me. We discussed the potential risks and benefits of Acthar Gel, including the most common side effects such as injection site reactions, physical weakness, and fluid retention, just to name a few.

I liked that he said I might not have to change my daily routine while treating with Acthar Gel. After 6 months of treatment with Acthar, I was told I no longer needed to treat my condition because my proteinuria levels were being managed. Of course, this is just my experience and experiences vary. My nephrologist told me the treatment would be delivered to my local pharmacy. My treatment journey began with a home visit from a Nurse Navigator* who showed me how to self-inject the medication. Now, I see my nephrologist every 6 months to monitor how things are going.

Everyone’s experiences are different. It’s important to talk to your healthcare provider if you have any questions or concerns about your treatment. Individual results may vary.

*Nurse Navigators do not provide medical advice, and patients should discuss any medical questions with their HCP.

 Meet John

Learn about John's experience treating proteinuria due to nephrotic syndrome with Acthar Gel.

2-minute read

NEXT:
Discover how Acthar Patient Support can help you start treatment if you and your doctor decide on Acthar Gel
What is Acthar Gel?
Toggle ISI tray

Acthar Gel is a prescription medicine used for:

  • Treatment for flares or on a regular basis (maintenance) in people with dermatomyositis or polymyositis (DM-PM)
  • Treatment for flares or on a regular basis (maintenance) in people with systemic lupus erythematosus (lupus)
  • Add-on therapy for short-term administration (to tide patients over an acute episode or exacerbation) in: psoriatic arthritis (PsA); rheumatoid arthritis (RA), including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy); ankylosing spondylitis
  • Treatment for people with symptomatic sarcoidosis
  • Treatment of severe acute and chronic allergic and inflammatory conditions affecting different parts of the eye. This can include the front part of the eye such as the cornea and iris, or the back part of the eye such as the optic nerve and retina
  • Reduction of proteinuria in people with nephrotic syndrome of the idiopathic type (unknown origin) without uremia (accumulation of urea in the blood due to malfunctioning kidneys) or that due to lupus erythematosus (lupus)
  • Treatment for adults with acute relapses or flares of multiple sclerosis (MS). Studies have shown Acthar to be effective in speeding recovery from an MS relapse. However, there is no evidence that it affects the ultimate outcome or natural history of the disease
  • Treatment of infantile spasms in infants and children under 2 years of age

Acthar is injected beneath the skin or into the muscle.

IMPORTANT SAFETY INFORMATION
Toggle ISI tray

DO NOT take Acthar until you have talked to your doctor if you have any of the following conditions:

  • Have been given or are about to receive a live or live attenuated vaccine
  • A skin condition called scleroderma
  • Bone density loss or osteoporosis
  • Any infections, including fungal, bacterial, or viral
  • Eye infections, such as ocular herpes simplex
  • Had recent surgery
  • Stomach ulcers or a history of stomach ulcers
  • Heart failure
  • Uncontrolled high blood pressure
  • Addison's disease or Cushing's syndrome
  • Allergies to pig-derived proteins
  • Suspected infections at birth (in infants under 2 years of age)

Tell your doctor about any other health problems that you have. Give your doctor a complete list of medicines you are taking, including all prescription and nonprescription medicines, vitamins, and herbal supplements.

What is the most important information I should know about Acthar?

  • Never inject Acthar directly into a vein
  • Acthar is injected beneath the skin or into the muscle. Always inject Acthar with SelfJect beneath the skin
  • Follow your doctor's instructions for injecting Acthar
  • Never stop treatment suddenly unless your doctor tells you to do so
  • Try not to miss any scheduled doctor's appointments. It is important for the doctor to monitor you while taking Acthar
  • You may be more likely to get new infections. Also, old infections may become active. Tell your doctor if you see any signs of an infection. Contact your doctor at the first sign of an infection or fever.
    Signs of infection are: fever, cough, vomiting, or diarrhea. Other signs may be flu or any open cuts or sores
  • When taking Acthar long-term, your adrenal gland may produce too much of a hormone called cortisol. This can result in symptoms of Cushing's syndrome. This may cause increased upper body fat, a rounded “moon” face, bruising easily, or muscle weakness
  • Sometimes when you stop taking Acthar long-term, your body may not produce enough natural cortisol. This is called "adrenal insufficiency." Your doctor may prescribe a steroid medicine to protect you until the adrenal gland recovers
  • You might develop high blood pressure, retain too much salt and water, or have low blood potassium levels. As a result of this, your doctor may recommend some changes to your diet, such as eating less salt or taking certain supplements
  • Vaccines may not work well when you are on Acthar. Talk to your doctor about which vaccines are safe to use while you are taking Acthar
  • Acthar may hide symptoms of other diseases. This can make it more difficult for your doctor to make a diagnosis of something else is going on
  • Stomach or intestinal problems. Acthar may increase the risk of bleeding and stomach ulcers. Tell your doctor if you have stomach pains, bloody vomit, bloody or black stools, excessive tiredness, increased thirst, difficulty breathing, or increased heart rate
  • Taking Acthar can make you feel irritable or depressed. You may also have mood swings or trouble sleeping. These effects are reversible once Acthar therapy is stopped
  • If you have other conditions, such as diabetes or muscle weakness, you may find they get worse
  • You might develop certain eye conditions, such as cataracts, glaucoma, or optic nerve damage
  • Your body may develop allergies to Acthar; these allergies may be severe. Signs of allergic reaction include:
    • Skin rash and itching
    • Swelling of the face, tongue, lips, or throat
    • Trouble breathing
  • The effects of Acthar may be intensified if you have an underactive thyroid or cirrhosis of the liver
  • Long-term Acthar use can affect growth and physical development in children. This can be reversed when Acthar is no longer needed
  • Acthar may cause osteoporosis (weak bones)
  • Acthar might harm an unborn baby. Therefore, tell your doctor if you are pregnant or plan to become pregnant

What are the most common side effects of Acthar?

Commonly reported side effects of Acthar include:

  • Injection site reaction
  • Fatigue, physical weakness, and lack of energy
  • Fluid retention
  • Insomnia (difficulty sleeping)
  • Headache
  • High blood sugar

The most common side effects for the treatment of infantile spasms (IS) are:

  • Increased risk of infections
  • Convulsions
  • High blood pressure
  • Irritability
  • Fever

The above side effects may also be seen in adults and children over 2 years of age. Some children with IS progress to other forms of seizures. IS sometimes makes these seizures, which may become visible after treatment for IS has been completed.

These are not all of the possible side effects of Acthar.

Tell your doctor about any side effect that bothers you, or that does not go away. Call your doctor or pharmacist for medical advice about side effects. You may report side effects to the FDA. Call 1-800-FDA-1088 or visit www.fda.gov/medwatch . You may also report side effects by calling 1-800-844-2830.

Please see the full Prescribing Information. If you've been prescribed SelfJect, please see the 40-unit or 80-unit Instructions for Use and the 40-unit or 80-unit Quick Reference Guide.

For parents and caregivers of children with infantile spasms, please also see Medication Guide.

Toggle ISI tray

What is Acthar Gel?

Acthar Gel is a prescription medicine used for:

  • Treatment for flares or on a regular basis (maintenance) in people with dermatomyositis or polymyositis (DM-PM)
  • Treatment for flares or on a regular basis (maintenance) in people with systemic lupus erythematosus (lupus)
  • Add-on therapy for short-term administration (to tide patients over an acute episode or exacerbation) in: psoriatic arthritis (PsA); rheumatoid arthritis (RA), including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy); ankylosing spondylitis
  • Treatment for people with symptomatic sarcoidosis
  • Treatment of severe acute and chronic allergic and inflammatory conditions affecting different parts of the eye. This can include the front part of the eye such as the cornea and iris, or the back part of the eye such as the optic nerve and retina
  • Reduction of proteinuria in people with nephrotic syndrome of the idiopathic type (unknown origin) without uremia (accumulation of urea in the blood due to malfunctioning kidneys) or that due to lupus erythematosus (lupus)
  • Treatment for adults with acute relapses or flares of multiple sclerosis (MS). Studies have shown Acthar to be effective in speeding recovery from an MS relapse. However, there is no evidence that it affects the ultimate outcome or natural history of the disease
  • Treatment of infantile spasms in infants and children under 2 years of age

Acthar is injected beneath the skin or into the muscle.

IMPORTANT SAFETY INFORMATION

DO NOT take Acthar until you have talked to your doctor if you have any of the following conditions:

  • Have been given or are about to receive a live or live attenuated vaccine
  • A skin condition called scleroderma
  • Bone density loss or osteoporosis
  • Any infections, including fungal, bacterial, or viral
  • Eye infections, such as ocular herpes simplex
  • Had recent surgery
  • Stomach ulcers or a history of stomach ulcers
  • Heart failure
  • Uncontrolled high blood pressure
  • Addison's disease or Cushing's syndrome
  • Allergies to pig-derived proteins
  • Suspected infections at birth (in infants under 2 years of age)

Tell your doctor about any other health problems that you have. Give your doctor a complete list of medicines you are taking, including all prescription and nonprescription medicines, vitamins, and herbal supplements.

What is the most important information I should know about Acthar?

  • Never inject Acthar directly into a vein
  • Acthar is injected beneath the skin or into the muscle. Always inject Acthar with SelfJect beneath the skin
  • Follow your doctor's instructions for injecting Acthar
  • Never stop treatment suddenly unless your doctor tells you to do so
  • Try not to miss any scheduled doctor's appointments. It is important for the doctor to monitor you while taking Acthar
  • You may be more likely to get new infections. Also, old infections may become active. Tell your doctor if you see any signs of an infection. Contact your doctor at the first sign of an infection or fever.
    Signs of infection are: fever, cough, vomiting, or diarrhea. Other signs may be flu or any open cuts or sores
  • When taking Acthar long-term, your adrenal gland may produce too much of a hormone called cortisol. This can result in symptoms of Cushing's syndrome. This may cause increased upper body fat, a rounded “moon” face, bruising easily, or muscle weakness
  • Sometimes when you stop taking Acthar long-term, your body may not produce enough natural cortisol. This is called "adrenal insufficiency." Your doctor may prescribe a steroid medicine to protect you until the adrenal gland recovers
  • You might develop high blood pressure, retain too much salt and water, or have low blood potassium levels. As a result of this, your doctor may recommend some changes to your diet, such as eating less salt or taking certain supplements
  • Vaccines may not work well when you are on Acthar. Talk to your doctor about which vaccines are safe to use while you are taking Acthar
  • Acthar may hide symptoms of other diseases. This can make it more difficult for your doctor to make a diagnosis of something else is going on
  • Stomach or intestinal problems. Acthar may increase the risk of bleeding and stomach ulcers. Tell your doctor if you have stomach pains, bloody vomit, bloody or black stools, excessive tiredness, increased thirst, difficulty breathing, or increased heart rate
  • Taking Acthar can make you feel irritable or depressed. You may also have mood swings or trouble sleeping. These effects are reversible once Acthar therapy is stopped
  • If you have other conditions, such as diabetes or muscle weakness, you may find they get worse
  • You might develop certain eye conditions, such as cataracts, glaucoma, or optic nerve damage
  • Your body may develop allergies to Acthar; these allergies may be severe. Signs of allergic reaction include:
    • Skin rash and itching
    • Swelling of the face, tongue, lips, or throat
    • Trouble breathing
  • The effects of Acthar may be intensified if you have an underactive thyroid or cirrhosis of the liver
  • Long-term Acthar use can affect growth and physical development in children. This can be reversed when Acthar is no longer needed
  • Acthar may cause osteoporosis (weak bones)
  • Acthar might harm an unborn baby. Therefore, tell your doctor if you are pregnant or plan to become pregnant

What are the most common side effects of Acthar?

Commonly reported side effects of Acthar include:

  • Injection site reaction
  • Fatigue, physical weakness, and lack of energy
  • Fluid retention
  • Insomnia (difficulty sleeping)
  • Headache
  • High blood sugar

The most common side effects for the treatment of infantile spasms (IS) are:

  • Increased risk of infections
  • Convulsions
  • High blood pressure
  • Irritability
  • Fever

The above side effects may also be seen in adults and children over 2 years of age. Some children with IS progress to other forms of seizures. IS sometimes makes these seizures, which may become visible after treatment for IS has been completed.

These are not all of the possible side effects of Acthar.

Tell your doctor about any side effect that bothers you, or that does not go away. Call your doctor or pharmacist for medical advice about side effects. You may report side effects to the FDA. Call 1-800-FDA-1088 or visit www.fda.gov/medwatch. You may also report side effects by calling 1-800-844-2830.

Please see the full Prescribing Information. If you've been prescribed SelfJect, please see the 40-unit or 80-unit Instructions for Use and the 40-unit or 80-unit Quick Reference Guide.

For parents and caregivers of children with infantile spasms, please also see Medication Guide.

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